Intralesional triamcinolone acetonide injection for primary and recurrent chalazia: is it really effective?

نویسندگان

  • Guy J Ben Simon
  • Lynn Huang
  • Tanuj Nakra
  • Robert M Schwarcz
  • John D McCann
  • Robert A Goldberg
چکیده

PURPOSE To evaluate the safety and efficacy of intralesional triamcinolone acetonide (TA) injection in primary and recurrent chalazia. DESIGN Retrospective, interventional, consecutive case series. PARTICIPANTS One hundred forty-seven patients with primary or recurrent chalazia (155 cases) treated at the oculoplastic clinic at the Jules Stein Eye Institute between January 1, 2000, and December 31, 2003. METHODS Patients received an intralesional injection of 0.1 to 0.2 ml TA (40 mg/ml). Data regarding lesion size, including digital color photography, lesion regression or recurrence, and complete ophthalmic examination, were recorded at the time of injection and at different intervals until resolution or surgical excision. Success was defined as at least an 80% decrease in size with no recurrence. If the lesion recurred or regression was minimal (<50%), further injections were given as needed. Patients who declined injection or who did not respond to 2 to 3 injections were referred for surgical excision and drainage. MAIN OUTCOME MEASURES Lesion size, clinical resolution, time to resolution, recurrence, and complications. RESULTS Most of the patients received 1 injection (93 patients; 60%) or 2 injections (31 patients; 20%) with resolution of the lesion (more than 80% decrease in size), with an average time to resolution of 2.5 weeks. Patients who did not respond to 2 injections were more likely to fail treatment (minimal or no regression), to respond to further injections, or to undergo surgical excision and drainage (P = 0.0001, chi-square test). Patients with blepharitis required more injections to resolution (2+/-1.3 vs. 1.4+/-1; P = 0.05, independent samples t test). Intraocular pressure and visual acuity remained stable after treatment. No complications, such as visual loss, subcutaneous fat atrophy, or skin depigmentation changes, were noted with steroids injections; assuming a complication rate of 2%, our power was adequate to rule out these complications. CONCLUSIONS Intralesional TA injection in primary and recurrent chalazia is effective in achieving lesion regression. Most cases resolve with an average of 1 to 2 injections. Chalazia that fail to respond to 2 or 3 injections are more likely to benefit from surgical excision. It may be considered as a first treatment in cases where diagnosis is straightforward.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Comparison of Intralesional Triamcinolone Acetonide Injection for Primary Chalazion in Children and Adults

PURPOSE To investigate outcome differences of intralesional triamcinolone acetonide (TA) injection for primary chalazia in children versus adults. METHODS A retrospective review of consecutive subjects with primary chalazion who received intralesional TA injection was conducted. A single investigator injected 0.05-0.15 mL of TA (40 mg/mL) intralesionally. Patients were stratified into the ped...

متن کامل

Intralesional triamcinolone acetonide injection for chalazion.

The aim of the study was to evaluate the efficacy of intralesional triamcinolone acetonide injection in primary and recurrent chalazion. The study included 30 patients with primary and recurrent chalazion (37 cases) and 24 patients as a control group. Patients with primary and recurrent chalazion received intralesional injection of 0.1 to 0.2 mL triamcinolone acetonide (40 mg/mL). Control group...

متن کامل

Chalazion management – surgical treatment versus intralesional injection of long acting steroids

Purpose: Comparison between the effectiveness of intralesional injection of long acting steroid (Triamcinolone acetonide) and surgical management (Incision and Curettage). Method: Hospital-based, two arm, prospective, comparative, interventional studyon 100patients who presented with chalazion who fulfill inclusion and exclusion criteria and gave informed consent were taken for the study. Preop...

متن کامل

Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas

Aim To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma. Patients and Methods This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children prese...

متن کامل

A noninvasive approach for management of recurrent oral mucocele in pediatric patients: a therapeutic case report

Background: Mucocele is a clinical term referring to a swelling caused by saliva accumulation at the site of an obstructed or traumatized minor salivary gland duct. This article reports the efficiency of intralesional corticosteroid injection in the treatment of a recurrent oral mucocele in a pediatric patient. Case presentation: A 7-year-old girl presented with the chief complaint of a painle...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Ophthalmology

دوره 112 5  شماره 

صفحات  -

تاریخ انتشار 2005